Queen Plaga

The Queen Plaga was an enormous immobile Plaga organism that appeared in Resident Evil 4. Appearing to be almost plant-like, this creature was the "mother" of the Plagas that had been revived by the Los Illuminados cult. The cult used the Queen to spawn new Plagas with which to convert new subjects into Ganados.

In 2004, the Illuminados had orchestrated the kidnapping of Ashley Graham, the daughter of the then-President of the United States. In a sinister ritual overseen by Ramon Salazar, Ashley was indoctrinated into the cult after being brought before the Queen Plaga. The precise details are unknown as the ritual was never witnessed.

US agent Leon Kennedy entered the tower where the Queen Plaga was housed and there he confronted Salazar. Salazar and his remaining Verdugo bodyguard were snatched up by the Queen's tentacles and absorbed into its form, becoming one with it. However, this wasn't enough to stop Leon who managed to kill the Queen Plaga and Salazar along with it.