Uroboros Aheri

The gargantuan Uroboros Aheri is a horrific amorphous beast that appears as a boss in Resident Evil 5. It was created when Albert Wesker injected Excella Gionne with the Uroboros virus and left her on the deck of the TRICELL tanker ship. When the virus overtook Excella, it reached out for the corpses of several Majini and consumed them, increasing its mass exponentially. After consuming so many bodies, it grew to almost 100 feet tall and covered nearly the whole front of the ship.

Chris Redfield and Sheva Alomar had no hope of destroying it with conventional weapons. However, a Satellite Laser Targeting System was conveniently placed near the bridge and the two agents were able to use it to destroy the monstrosity before it tore the ship apart.